Genetic Power Calculator

QTL Association for Sibships

 Total QTL variance               :  (0 - 1)
 Dominance : additive QTL effects :  (0 - 1)  No dominance (* see below) 
 QTL increaser allele frequency   :  (0 - 1)
 Marker M1 allele frequency       :  (0 - 1)
 Linkage disequilibrium (D-prime) :  (0 - 1) 
 Sibling correlation              :  (0 - 1) (* see below)



 Sample Size                      :   (0 - 10000000) (N=families, not individuals) 
 Sibship Size                     :   Both parents genotyped


 User-defined type I error rate   :  (0.00000001 - 0.5)
 User-defined power: determine N  :  (0 - 1)
 (1 - type II error rate)

Note : By default, power is calculated for a 2 degree of freedom test, testing for additive QTL effects as well as dominance. If the No dominance button is checked then only the additive QTL effects are tested. Note, that this implicitly sets the dominance:additive effects ratio to 0. That is, if you do not test for dominance, then you cannot specify it in the model.

Note : sibling correlation must be greater than or equal to half of the additive genetic variance and one quarter of the dominance genetic variance. If this condition is not met, the shared residual variance will be negative (this can be easily checked in the ouput).

Last updated 4th September by Shaun Purcell